Pentraxin 3, Mouse, mAb 2C3

SKU: HYBHM1130100UG

Available Quantity : 0

Monoclonal antibody 2C3 recognizes mouse pentraxin 3 (PTX3). The first line of defense against pathogens is represented by the innate immune system. An important part of this system is the recognition of pathogen associated molecular patterns (PAMPs) by pattern recognition molecules (PRMs). Pentraxins (PTXs) are a family of soluble cyclic pentameric PRMs. Based on primary structure, they can be divided in two groups, short and long PTXs. C-reactive protein (CRP) and serum amyloid P component (SAP) are prototypic short PTXs. Others have been classified as long PTXs. PTXs have a conserved ca 200 amino acid long c-terminal domain containing the PTX signature (HxCxS/TWxS, where x is any amino acid). Human PTX3 encodes a 381 amino acid, 45 kDa secretory glycoprotein with a 162 amino acid N-terminal extension and a 202 amino acid C-terminal pentraxin domain. There is also a high degree of conservation between from mouse to man. PTX3 is the prototypic long PTX and was originally identified in endothelial cells and fibroblasts. Orthologs of PTX3 have been found in a variety of species. The PTX3 gene consists of three exons and two introns. The first two exons code for the leader peptide and the N-terminal domain of the protein, respectively, and the third exon encodes the pentraxin domain. PTX3 expression can among others be induced by proinflammatory cytokines like TNFα, Il1β and TLR agonists. Whereas short PTXs are produced in the liver, the main source of PTX3 expression are myeloid dendritic cells but expression is also seen in monocytes, macrophages, endothelial cells (constitutively expressed), fibroblasts, smooth muscle cells, kidney epithelial cells, synovial cells, chondrocytes, adipocytes, alveolar epithelial cells, granulosa cells and glial cells.

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Sales Unit: 100UG

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