PODS® Mouse GM-CSF, 25 µg

PODS® proteins are made using an insect cell expression system in which the active protein is co-expressed alongside polyhedrin carrier protein. Polyhedrin forms microcrystals within insect cells which specifically capture the active protein to form a co-crystal complex. The active protein is captured in its nascent, natively folded form with limited scope for proteolytic degradation. Consequently, excellent levels of bioactivity are observed. The PODS® co-crystals provide a sustained release mechanism and can be used to functionalize surfaces. For further details, please refer to the PODS® Technology page.

The product contains polyhedrin protein co-crystalized with mature mouse Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF). GM-CSF is a cytokine that stimulates the growth and differentiation of hematopoietic precursor cells including granulocytes, eosinophils, erythrocytes, and macrophages. Mature mouse GM-CSF shares 54% and 69% amino acid sequence identity with human rat GM-CSF respectively. The activity of the human and mouse GM-CSF is species-specific. Rat GM-CSF is fully active on mouse cells, but mouse GM-CSF is weakly active on rat cells. GM-CSF is involved in immune response, allergy, inflammatory processes, angiogenesis and, autoimmunity.