Sorafenib, 1 g

Sorafenib is a multikinase inhibitor with activity against Raf kinase and several receptor tyrosine kinases including vascular endothelial growth factor receptor 2 (VEGFR2) platelet-derived growth factor receptor (PDGFR) FLT3 Ret and c-Kit. It suppresses ERK phosphorylation. It also induces the phosphorylation of PKA.