Stauprimide

Stauprimide is an indolocarbazole semi-synthetic small molecule. Stauprimide inhibits the nuclear localization of NME2 blocking and downregulating c-Myc expression. The expression of c-Myc is crucial for embryonic stem cell (ESC) self-renewal and intervention by Stauprimide allows for more efficient lineage-specific differentiation. NME2 is also indicated to be upregulated in certain cancers indicating further application for the blocking action of this small molecule.