U0126, 300MG

U0126 is a selective MAP Kinase inhibitor displaying a preference for MEK-1 and MEK-2. It is known that U0126 binds to MEK in a noncompetitive manner compared to ATP. Studies suggest that U0126 antagonizes the transcription of AP-1 via the inhibition of MEK. In addition U0126 has been observed to inhibit promoters containing an AP-1 response element while in contrast having no effect on promoters that lack an AP-1 response group. U0126 is an activator of PGC-1 mtTFA and Nuclear Respiratory Factor.