CSI E-Chronicle - January 2019
 

The e-Chronicle is a monthly publication from Chromatographic Specialties Inc. It showcases new products, suppliers, literature and news from across the chromatography industry.
 


NEW SUPPLIER

 

Faster Chemistry – FastWoRX™ Liquid-Liquid Extraction Alternative
 

Forget the Separatory Funnel!

  • Ideal for reaction work-ups or for extracting from particle laden environmental samples
  • Solvent Savings
    • Reduce 20 - 50 mL of solvent needed for traditional LLE to 0 - 5 mL with FastWoRX
  • Time Savings
    • LLE-based extraction work flow adds up to approximately 50 min / sample
    • FastWoRX-based work flow typically takes 15 min or less to reach the same point
  • Safety
    • Reduction in potential contact with hazardous reagents and solvents
       

Click here for more information.
Click here to order or request a quote.

 

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NEW PRODUCTS

 

YMC – SEC MAB Columns for Monoclonal Antibody Analysis
 

This silica-based size exclusion chromatography column is optimized for separating both aggregates and fragments of monoclonal antibodies. Additionally, it can be used for analyzing antibody drug conjugates by using organic-containing mobile phases which reduce hydrophobic interactions.

  • Excellent lot-to-lot reproducibility: Virtually no lot-to-lot variability providing excellent reproducibility for effective quality control methods.  Exhibits low non-specific adsorption with improved stability for long column lifetime.
     
  • Exceptional resolution: Provides competitive performance to similar 3µm SEC products currently available on the market. For both HMW and LMW species, resolution is significantly improved.
     
  • Designed for antibody sizing separations: Developed on a 3µm, 250Å pore size particle useful for separating aggregates from monomer, as well as providing increased resolution for lower molecular weight fragments.


Click here for more information.  (Link to YMC website)
Click here to order or request a quote. 

 


HTA – HT4000L Autosampler with Double Valve Set
 

One single autosampler can serve 2 separate analyzers: 2 HPLCs, 2 UHPLCs, 2 ICs or a mix of any 2 of those systems.  Injections can be performed alternately in the 2 systems or only in one of them, if the other one is temporarily left unused. 

The HT4000L with double valve option is a more economical alternative to buying 2 separate autosamplers. 
 

Click here for more information.
Click here to order or request a quote. 

 

 

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FEATURED PRODUCT

 

Optimize Technologies and VICI – Make Better Solvent Connections for HPLC and UHPLC
 

Optimize Technologies – Universal LC Accessories

Optimize Technologies is dedicated to providing the highest quality HPLC, UHPLC and LC/MS products available. They combine innovative design and superior performance to create products that are straight forward, yet elegant, solutions to daily issues in the lab.

  • EXP® - Reusable hand-tight connections and cartridge replacement for UHPLC pressures of 20,000+ psi
  • Opti-Lynx™ - Low-dispersion quick-connect capabilities for many applications rated to 6,000 psi
  • Opti-Seal® and ITB™- Piston seals with unique polymer blends to provide the ultimate performance
  • Opti-Max® - Check valves feature optimized geometry for the fastest response time and flawless operation


Click here for more information.
Click here to order or request a quote.

 

VICI - Safety Caps

Sealed solvent and waste bottles with air intake check valves, and charcoal scrubbers on exhaust improve your laboratory's performance.

  • No evaporation of volatile compounds into lab air – better air quality without expensive HVAC upgrades
  • Better composition stability of the mobile phases, less shift of retention times
  • No bacterial contamination, 0.2 µm inlet filters remove dust and bacteria from air drawn into solvent bottles, extend the life of aqueous mobile phases


Click here for more information.
Click here to order or request a quote. 

 

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EVENTS

 

Activated Research Company - FREE Webinar: Universal Carbon Detection for GC and LC
 

Date: Thursday, January 17, 2019
Time: 2:00 pm to 3:00 pm Eastern Time

Click here to register.

The gas chromatograph (GC) is an extremely robust instrument that is widely used for the analysis of volatile organic compounds (VOCs).  With a large linear dynamic range and sub-ppm sensitivity, the flame ionization detector (FID) has been a workhorse detector across many industries, including chemicals, oil & gas, paints & coatings, flavour & fragrance, and more.  While the FID is one of the most widely used GC detectors, quantification using the FID can be a costly and time-intensive process due to the rigorous calibration process.  Moreover, even the most expensive calibration standards are susceptible to degradation, volatility, mishandling and even poor preparation that lead to inaccuracies.  A better way of quantification is required for accurate and efficient analysis in the new age. 

In this webinar, ARC will highlight recent advances in the GC and LC space which improve productivity, increase safety, and reduce waste through the concept of compound independent calibration. These advances open new capabilities in the laboratory by harnessing the latest in additive manufacturing and catalytic technologies.

In this webinar, you will learn about:

  • Compound independent calibration of VOCs in GC allowing more than a 10x decrease in analysis time
  • ppb-level analysis of CO, CO2 and formaldehyde
  • Compound independent calibration in HPLC with solvent removal and reaction

Click here to register.

 

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TECHNICAL TIPS

 

Restek - Pressure Decay Test for GC Video
 

Leaks are one of the most common issues with gas chromatography and they can cause poor results and impact instrument performance. Finding and eliminating leaks is a critical skill to keeping your instrument running at its best. Pressure decay tests are an age-old tool for identifying the presence of a leak and we’ll tell you how to do one in this video.


Click here to watch the video. (Link to YouTube)

 


Optimize Technologies – How to Use Free-Turn™ Housings
 

Optimize Free-Turn™ housings for HPLC products, including filters, guard columns, and pump check valves, provide for faster and easier instrument maintenance by eliminating the need to disconnect tubing when changing the filter, guard cartridge or check valve.  This cuts the number of fittings you need to disconnect and re-connect in half, saving time and wear and tear on your equipment (and on you).

Some tips for getting the most out of Free-Turn™ and similar products such as VICI caps:

  1. Take time to make your initial tubing connections as well as possible. You should not need to make them again.
    • Make sure your tubing bottoms out properly for a true zero-dead-volume (ZDV) connection.
      • Do not re-use stainless steel fittings made up in another fitting
      • Check that your tubing is cut squarely
      • Check PEEK tubing has not been crimped from repeated connections
    • Use good quality 2-piece fittings (separate nuts and ferrules)
      • With a 1-piece fitting, the ferrule is forced to rotate as the nut is tightened, rather than compressing without rotation
      • More compressive force is required to get the same seal with a 1-piece fitting than would be required with a separate nut and ferrule.
      • Since the tubing connection is only made once, the slight extra juggling needed to use a separate nut and ferrule once pays off in the better long term seal
         
  2. When opening a Free-Turn™ housing
    Typically opening a free turn housing is a simple as unscrewing the housing body, either as two halves for a filter or guard holder or from a pump body in the case of a check valve.  If the housing hasn’t been opened in some time, you may need to hold the receiving fitting for the tubing (just above the wrench in picture 1) with a second wrench as you break the static friction between the parts. After the first 1/8th turn of the housing you won’t need the 2nd wrench.
     

 

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